Clinical, electrophysiological, molecular, and genetic characteristics of patients with Wolf–Parkinson–White syndrome: literature review

The WolfParkinsonWhite (WPW) syndrome is a condition with early excitation of the heart ventricles due to conduction an electrical pulse along atrioventricular pathway, such as Kent, James bundle, and Mahaim fibers; usually accompanied by supraventricular tachycardia, reciprocal tachycardia in 95% cases, fibrillation, atrial flutter, other cases. WPW can be observed patients any age, approximately 130 per 10,000 people, male predominance. disease affects 0.150.25% population. Sudden cardiac death occurs one patient 1000 annually, sometimes this first "business card" disease. This mainly lightning-fast formation life-threatening arrhythmias, for example, transformation fibrillation into ventricular fibrillation. morphological substrate additional connection. Currently, transcatheter radiofrequency ablation standard interventional treatment syndrome. has diverse etiology. Numerous studies reported that genetics play significant role development Several genetic predictors are presented modern literature, which may relevant predicting diagnosing hidden forms syndrome, course, symptoms manifestations, reduction risks sudden death.